TECFIDERA is contraindicated in patients with known hypersensitivity to dimethyl fumarate or to any of the excipients of TECFIDERA. Reactions have included anaphylaxis and angioedema.
Signs and symptoms
For additional information, please see full Prescribing Information.
*Flushing consists of the preferred terms of flushing and hot flush. Other related symptoms consist of the preferred terms of erythema, generalized erythema, burning sensation, skin burning sensation, feeling hot, and hyperemia.
†A high-fat, high-calorie meal did not affect the overall exposure to MMF, a TECFIDERA metabolite, but decreased the maximal plasma concentration and increased the time until this concentration was reached. A high-fat, high-calorie meal reduced the incidence of flushing by approximately 25%.