Consider interruption of treatment in patients with lymphocyte counts <0.5x109/L persisting for >6 months. Discontinue treatment if significant liver injury is suspected.
*A high-fat, high-calorie meal did not affect the overall exposure to MMF, a TECFIDERA metabolite, but decreased the maximal plasma concentration and increased the time until this concentration was reached. A high-fat, high-calorie meal reduced the incidence of flushing by approximately 25%.1
References: 1. TECFIDERA Prescribing Information, Biogen, Cambridge, MA. 2. Biogen, Data on file.